First human ‘pangenome’ aims to catalogue genetic diversity

The first draft of a human ‘pangenome’ has been published. Unlike the first complete human genome sequence, which was derived mostly from the DNA of just one person, the pangenome is drawn from 47 people from around the globe, including individuals from Africa, the Americas, Asia and Europe. More genomes are being added — 350 will be analysed by mid-2024. They will allow geneticists to identify variations in the genomes of diverse populations and investigate links between genes and disease.